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Article

Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction.

Circulation. Genomic and precision medicine - 1 Apr 2021

Riveros-Mckay Fernando, Weale Michael E, Moore Rachel, Selzam Saskia, Krapohl Eva, Sivley R Michael, Tarran William A, Sørensen Peter, Lachapelle Alexander S, Griffiths Jonathan A, Saffari Ayden, Deanfield John, Spencer Chris C A, Hippisley-Cox Julia, Hunter David J, O'Sullivan Jack W, Ashley Euan A, Plagnol Vincent, Donnelly Peter

Abstract excerpt

BACKGROUND: There is considerable interest in whether genetic data can be used to improve standard cardiovascular disease risk calculators, as the latter are routinely used in clinical practice to manage preventative treatment. METHODS: Using the UK Biobank resource, we developed our own polygenic risk score for coronary artery disease (CAD). We used an additional 60 000 UK Biobank individuals to develop an...

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Identifiers

PMID: 33651632
DOI: 10.1161/CIRCGEN.120.003304
PMCID: PMC8284388

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