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Article

Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later.

Genome medicine - 28 Jan 2021

Isgut Monica, Sun Jimeng, Quyyumi Arshed A, Gibson Greg

Abstract excerpt

BACKGROUND: Several polygenic risk scores (PRS) have been developed for cardiovascular risk prediction, but the additive value of including PRS together with conventional risk factors for risk prediction is questionable. This study assesses the clinical utility of including four PRS generated from 194, 46K, 1.5M, and 6M SNPs, along with conventional risk factors, to predict risk of ischemic heart disease (IHD),...

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Identifiers

PMID: 33509272
DOI: 10.1186/s13073-021-00828-8
PMCID: PMC7845089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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