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Article

Incremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review.

JAMA internal medicine - 1 Oct 2022

Groenendyk Jacob William, Greenland Philip, Khan Sadiya S

Abstract excerpt

Importance: Risk prediction for coronary heart disease (CHD) is a cornerstone of primary prevention strategies. Polygenic risk scores (PRSs) have emerged as a new approach to predict risk in asymptomatic people. Polygenic risk scores for CHD have been studied in several populations, but there is lack of agreement about the incremental value of PRS beyond traditional risk factor scores in the primary prevention of...

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Identifiers

PMID: 35994254
DOI: 10.1001/jamainternmed.2022.3171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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