Article

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules

2025-05-29

Abstract excerpt

Exposure to hypoxia is linked to increased cellular plasticity and enhanced metastasis; effects which are primarily attributed to the transcriptional activation of large gene programs downstream of hypoxia inducible factors (HIFs). However, translational effects in hypoxia, that likely precede transcriptional effects, have remained largely unexplored. Using ribosome-profiling, we uncovered a selective translationa...

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Literature Corpus work: b329a617-b98a-5c59-b53e-38e566af1478
DOI: 10.1101/2025.05.29.656739

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