Article
Translational control of aberrant stress responses as a hallmark of cancer.
The Journal of pathology - 1 Apr 2018
El-Naggar Amal M, Sorensen Poul H
Abstract excerpt
Altered mRNA translational control is emerging as a critical factor in cancer development and progression. Targeting specific elements of the translational machinery, such as mTORC1 or eIF4E, is emerging as a new strategy for innovative cancer therapy. While translation of most mRNAs takes place through cap-dependent mechanisms, a sub-population of cellular mRNA species, particularly stress-inducible mRNAs with...
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