Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

Nature - 4 Jun 2015

Lee Amy S Y, Kranzusch Philip J, Cate Jamie H D

Abstract excerpt

Regulation of protein synthesis is fundamental for all aspects of eukaryotic biology by controlling development, homeostasis and stress responses. The 13-subunit, 800-kilodalton eukaryotic initiation factor 3 (eIF3) organizes initiation factor and ribosome interactions required for productive translation. However, current understanding of eIF3 function does not explain genetic evidence correlating eIF3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ribosomes
Share to 5' Untranslated Regions
Share to Cross-Linking Reagents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Eukaryotic Initiation Factor-3

Share to Immunoprecipitation

Share to Organ Specificity

Share to Peptide Chain Initiation, Translational

Share to Proto-Oncogene Proteins c-jun

Source

Open in PubMed Open full text

Identifiers

PMID: 25849773
DOI: 10.1038/nature14267
PMCID: PMC4603833

Genes

BTG1
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.PMID 25849773Read ↗

eIF3 engages with 3’-UTR termini of highly translated mRNAsSemantic proximity Read ↗

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small moleculesSemantic proximity Read ↗

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAsSemantic proximity Read ↗

Comprehensive analysis of biological networks and the eukaryotic initiation factor 4A‐3 gene as pivotal in hepatocellular carcinomaSemantic proximity Read ↗

RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferationSemantic proximity Read ↗

eIF3 interactions with miRNAs involved in translational control of early T cell activationSemantic proximity Read ↗

A burst in T cell receptor translation mediated by eIF3 interactions with T cell receptor mRNAsSemantic proximity Read ↗

PI3Kδ activates E2F1 synthesis in response to mRNA translation stressSemantic proximity Read ↗

Repression of ferritin light chain translation by human eIF3Semantic proximity Read ↗

Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarraySemantic proximity Read ↗

Repression of ferritin light chain translation by human eIF3Semantic proximity Read ↗

Structural Roles for Human Translation Factor eIF3 in Initiation of Protein SynthesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.