Article
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.
Nature - 4 Jun 2015
Lee Amy S Y, Kranzusch Philip J, Cate Jamie H D
Abstract excerpt
Regulation of protein synthesis is fundamental for all aspects of eukaryotic biology by controlling development, homeostasis and stress responses. The 13-subunit, 800-kilodalton eukaryotic initiation factor 3 (eIF3) organizes initiation factor and ribosome interactions required for productive translation. However, current understanding of eIF3 function does not explain genetic evidence correlating eIF3...
Topics
- 5' Untranslated Regions
- Apoptosis
- Binding Sites
- Cell Differentiation
- Cell Line
- Cell Proliferation
- Cross-Linking Reagents
- Down-Regulation
- Eukaryotic Initiation Factor-3
- Humans
- Immunoprecipitation