Article

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

2024-05-11

Abstract excerpt

The majority of human breast cancers are dependent on hormone-stimulated estrogen receptor alpha (ER) and are sensitive to its inhibition. Treatment resistance arises in most advanced cancers due to genetic alterations that promote ligand independent activation of ER itself or ER target genes. Whereas re-targeting of the ER ligand binding domain (LBD) with newer ER antagonists can work in some cases, these drugs a...

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Literature Corpus work: 8cdd2227-22c9-5f07-9962-c212c3ff1d50
DOI: 10.1101/2024.05.08.593195

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