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Article

Targeting the eIF4F translation initiation complex for cancer therapy

15 Aug 2008

Abstract excerpt

In multiple human cancers, the function of the eukaryotic translation initiation factor 4E (eIF4E) is elevated and directly related to disease progression. Overexpression or hyperactivation of eIF4E in experimental models can drive cellular transformation and malignant progression. Elevated eIF4E function triggers enhanced assembly of the eIF4F translation initiation complex and thereby drives cap-dependent...

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PMID: 18719377
DOI: 10.4161/cc.7.16.6464

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