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Robust eIF4B levels undermine invasive growth and immune evasion mechanisms in murine triple negative breast cancer models

2022-09-18

Abstract excerpt

Dysregulated protein synthesis is seen in many aggressive cancers, including metastatic breast cancer. However, the specific contributions of certain translation initiation factors to in vivo disease remain undefined. This is particularly true of eIF4B, an RNA-binding protein and cofactor of the RNA helicase eIF4A and associated eIF4F cap-binding complex. While eIF4A, eIF4G, and eIF4E are well-known to contribute...

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Literature Corpus work
a552b4d3-22a8-5f4b-8551-c0449e7d9ba6
DOI
10.1101/2022.09.16.508318
Open publication

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Robust eIF4B levels undermine invasive growth and immune evasion mechanisms in murine triple negative breast cancer modelsDOI 10.1101/2022.09.16.508318
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