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Article

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

1 Feb 2008

Abstract excerpt

The eukaryotic translation initiation factor 4E (eIF4E) is frequently overexpressed in human cancers in relation to disease progression and drives cellular transformation, tumorigenesis, and metastatic progression in experimental models. Enhanced eIF4E function results from eIF4E overexpression and/or activation of the ras and phosphatidylinositol 3-kinase/AKT pathways and selectively increases the translation of...

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PMID: 18245460
DOI: 10.1158/0008-5472.can-07-5635

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