Article

Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factor

2023-08-22

Abstract excerpt

Tumor cells often exploit the protein translation machinery, resulting in enhanced protein expression essential for tumor growth. Since canonical translation initiation is often suppressed due to cell stress in the tumor microenvironment, non-canonical translation initiation mechanisms become particularly important for shaping the tumor proteome. EIF4G2 is a non-canonical translation initiation factor that mediate...

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Literature Corpus work: 65e7b0ac-8b32-56cf-ab6a-ddb31bb4f147
DOI: 10.1101/2023.08.22.554280

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