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Article

Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer

26 Oct 2012

Abstract excerpt

Abstract Introduction Translation initiation is activated in cancer through increase in eukaryotic initiation factor 4E (eIF4E), eIF4G, phosphorylated eIF4E-binding protein (p4E-BP1) and phosphorylated ribosomal protein S6 (pS6), and decreased programmed cell death protein 4 (pdcd4), a translational inhibitor. Further, translation elongation is deregulated though alterations in eukaryotic elongation factor 2...

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PMID: 23102376
DOI: 10.1186/bcr3343

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