Article

Effective inhibition of MYC-amplified Group 3 medulloblastoma through targeting translation machinery eIF4F complex

2020-03-25

Abstract excerpt

<h4>Background: </h4> Medulloblastoma (MB) consists of four major molecular subtypes and group 3 subtype (G3) is the most aggressive one. MYC amplification tends to happen in G3 MB and those patients exhibit the worse prognosis and need novel effective therapeutic approach most urgently. MYC has been shown to be the driver as well as crucial dependency for MYC-amplified G3-MB, thus serving as a promising therapeut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e152d267-f066-55c7-9ca9-7b02bb98b072
DOI: 10.21203/rs.3.rs-19096/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effective inhibition of MYC-amplified Group 3 medulloblastoma through targeting translation machinery eIF4F complexDOI 10.21203/rs.3.rs-19096/v1Read

The <i>EIF4EBP1</i> gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastomaSemantic proximity Read

N-myc–Mediated Translation Control Is a Therapeutic Vulnerability in MedulloblastomaSemantic proximity Read

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cellsSemantic proximity Read

Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in NeuroblastomaSemantic proximity Read

Characterization of an RNA binding protein interactome reveals the targetable post-transcriptional landscape of MYC-amplified medulloblastomaSemantic proximity Read

Targeting the eIF4F translation initiation complex for cancer therapySemantic proximity Read

Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLLSemantic proximity Read

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small moleculesSemantic proximity Read

PRMT5 as an Epigenetic Target for Group 3 (MYC-driven) MedulloblastomaSemantic proximity Read

MELK inhibition effectively suppresses growth of glioblastoma and cancer stem-like cells by blocking AKT and FOXM1 pathwaysSemantic proximity Read

MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastomaSemantic proximity Read

Deep computational analysis of human cancer and non-cancer tissues details dysregulation of eIF4F components and their interactions in human cancersSemantic proximity Read