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Article

Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma

2 Sept 2014

Abstract excerpt

Enhanced protein synthesis capacity is associated with increased tumor cell survival, proliferation, and resistance to chemotherapy. Cancers like multiple myeloma (MM), which display elevated activity in key translation regulatory nodes, such as the PI3K/mammalian target of rapamycin and MYC-eukaryotic initiation factor (eIF) 4E pathways, are predicted to be particularly sensitive to therapeutic strategies that...

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Share to Monoclonal and Polyclonal Antibodies Research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25197055
DOI: 10.1073/pnas.1402650111

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