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Article

The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.

Cell death & disease - 22 Jan 2015

Modelska A, Turro E, Russell R, Beaton J, Sbarrato T, Spriggs K, Miller J, Gräf S, Provenzano E, Blows F, Pharoah P, Caldas C, Le Quesne J

Abstract excerpt

Human mRNA DeXD/H-box helicases are ubiquitous molecular motors that are required for the majority of cellular processes that involve RNA metabolism. One of the most abundant is eIF4A, which is required during the initiation phase of protein synthesis to unwind regions of highly structured mRNA that would otherwise impede the scanning ribosome. Dysregulation of protein synthesis is associated with tumorigenesis,...

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Identifiers

PMID: 25611378
DOI: 10.1038/cddis.2014.542
PMCID: PMC4669741

Genes

PDCD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.PMID 25611378Read ↗

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