Article

Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer’s disease

2025-07-15

Abstract excerpt

<title>Abstract</title> <p>APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), but its contribution to disease pathogenesis remains incompletely understood. Here, we integrate proteomic profiling of plasma, cerebrospinal fluid (CSF), and brain tissue from over 10,000 individuals to define the immune phenotype associated with APOE ε4. We identify a conserved, allele dose-dependent...

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Literature Corpus work: b1b9032a-ba78-5e60-844a-8c7ae773a881
DOI: 10.21203/rs.3.rs-7089423/v1

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