Article

Single-cell multi-omic profiling allows the dissection of peripheral immune phenotypes in Alzheimer’s Disease progression

2026-03-13

Abstract excerpt

<h4>Summary</h4> The role of the peripheral immune system in Alzheimer’s Disease (AD) remains insufficiently resolved, limiting the understanding of systemic disease effects and mechanisms. Here, we employed three high-resolution single-cell techniques, including flow cytometry, single-cell RNA- and ATAC-sequencing, to investigate peripheral immunity in AD dementia and earlier stages of the AD trajectory in over...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a990ff1f-3184-576d-958e-3cec6a81dfdf
DOI: 10.64898/2026.03.12.26348228

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omic profiling allows the dissection of peripheral immune phenotypes in Alzheimer’s Disease progressionDOI 10.64898/2026.03.12.26348228Read

Exploratory Single-Cell RNA Sequencing of Peripheral Blood Identifies Candidate Signatures Associated with Alzheimer’s DiseaseSemantic proximity Read

Genomic partitioning of Alzheimer’s disease in humans reveals non-CNS etiologySemantic proximity Read

Single-Cell RNA Sequencing of Peripheral Blood Reveals Immune Cell Signatures in Alzheimer’s DiseaseSemantic proximity Read

The Peripheral Immune-Sleep- Cognition Axis Across Diagnostic Stages of Alzheimer’s DiseaseSemantic proximity Read

Deciphering the peripheral immune landscape of Alzheimer's disease through integrated multi-omics research and cohort validation.Semantic proximity Read

Tracking the progression of Alzheimer’s disease with peripheral blood monocytesSemantic proximity Read

Adaptive immune changes associate with clinical progression of Alzheimer’s diseaseSemantic proximity Read

Immunological Differences in Atopic Dermatitis Across Age Groups: Insights from Single-Cell Multi-OmicsSemantic proximity Read

Population and single-cell analyses reveal immune cell-specific expression profiles associated with Alzheimer's disease risk.Semantic proximity Read

Altered T-cell reactivity in the early stages of Alzheimer's diseaseSemantic proximity Read

Identification of altered immune cell types and molecular mechanisms in Alzheimer’s disease progression by single-cell RNA sequencingSemantic proximity Read

Cell States and Interactions of CD8 T Cells and Disease-Enriched Microglia in Human Brains with Alzheimer’s DiseaseSemantic proximity Read