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The <i>APOE</i> isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease

2024-07-05

Abstract excerpt

Microglia play a key role in the response to amyloid beta in Alzheimer’s disease (AD). In this context, a major transcriptional response of microglia is the upregulation of APOE , the strongest late-onset AD risk gene. Of its three isoforms, APOE2 is thought to be protective, while APOE4 increases AD risk. We hypothesised that the isoforms functionally alter microglia by shaping their transcriptomic and chromat...

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Literature Corpus work
d8eb6a2e-be74-5340-b10e-5f18277123ed
DOI
10.1101/2024.07.03.601874
Open publication

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The <i>APOE</i> isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s diseaseDOI 10.1101/2024.07.03.601874
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