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Proteomic Signatures of Protected <i>APOE</i> -ε4 Carriers Reveal Causal Pathways Associated with Delayed Alzheimer’s Disease Onset

2026-05-01

Abstract excerpt

<h4>Structured Abstract</h4> <h4>INTRODUCTION</h4> APOE -ε4 is the strongest common genetic risk factor for Alzheimer’s disease (AD), yet many carriers remain cognitively unimpaired into late life. We tested whether a protected-ε4-first proteomic approach could identify plasma proteins associated with delayed clinical onset among ε4 carriers. <h4>METHODS</h4> We analyzed harmonized plasma proteomics from the G...

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Literature Corpus work: d29383ef-4e2d-5fa5-bf85-5599f15cc775
DOI: 10.64898/2026.04.30.26352191

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