Article

APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer’s Disease

2026-06-19

Abstract excerpt

<h4>ABSTRACT</h4> Variation in APOE, notably the ε4 allele, profoundly shapes risk and severity of late-onset Alzheimer’s disease (AD), yet how it remodels human microglial states remains unresolved. We combine spatially resolved proteomic profiling with single-nuclear multiomic analyses to define microglial organization across APOE3/3 and APOE4/4 genotypes in AD. Quantifying condition-associated variation across...

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Literature Corpus work: 94f4be60-1dc9-501a-bd48-7d7bee470ab7
DOI: 10.64898/2026.06.18.733295

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