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Cerebrospinal fluid proteomic signatures reveal APOE genotype-dependent lipid and immune profiles in cognitively unimpaired elderly

2026-02-05

Abstract excerpt

<title>Abstract</title> <p>Cerebrospinal fluid (CSF) proteomics offers insights into molecular changes in aging and Alzheimer’s disease (AD). Key AD biomarkers, in particular amyloid-β (Aβ) and tau, in CSF are strongly associated with APOE genotype, the strongest genetic risk determinant of AD. To investigate how APOE genotype influences CSF proteome across AD pathology and age, we analyzed 362 neurology-related...

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Literature Corpus work: 36f67e82-7f3a-5023-a4ba-311d852797c9
DOI: 10.21203/rs.3.rs-8605807/v1

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