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Article

Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2026

Shvetcov Artur, Thomson Shannon, Graham Mark E, Hauger Brittany, Keller Jessica E, Smoyer Christine J, Tague Sarah E, Cho Ann-Na, Imam Farhad B, Krish Varsha, Taylor Matthew K, Mahnken Jonathan D, Sullivan Debra K, Reed Joanne H, Burns Jeffrey M, Slawson Chad, Swerdlow Russell H, Wilkins Heather M, Finney Caitlin A

Abstract excerpt

INTRODUCTION: Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), but its contribution to disease pathogenesis remains incompletely understood. METHODS: Here, we integrate proteomic profiling of plasma (n = 9028), cerebrospinal fluid (n = 1099), dorsolateral prefrontal cortex (n = 720), and superior temporal gyrus (n = 105) to define the immune phenotype...

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Topics

Humans
Alzheimer Disease
Apolipoprotein E4
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Proteomics

Male

Aged

Temporal Lobe

Prefrontal Cortex

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42671246
DOI: 10.1002/alz.71714
PMCID: PMC13528450

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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