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Article

Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease.

Nature aging - 1 May 2026

Lu Lina, Pichet Binette Alexa, Hristovska Ines, Janelidze Shorena, Smets Bart, Cumplido-Mayoral Irene, Vasanthakumar Aparna, Milkovich Britney, An Lijun, Ossenkoppele Rik, Krish Varsha, Imam Farhad, Palmqvist Sebastian, Vogel Jacob W, Stomrud Erik, Hansson Oskar, Mattsson-Carlgren Niklas

Abstract excerpt

The APOE locus is the strongest genetic factor for Alzheimer's disease, with ε4 increasing and ε2 decreasing risk, yet the basis of these opposing effects remains unclear. Here we performed a multicohort proteomic analysis across plasma and cerebrospinal fluid in GNPC, BioFINDER-2, ADNI, UK BioBank, and PPMI. APOE-associated protein alterations are detectable before amyloid pathology and remain stable across age...

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Identifiers

PMID: 42141098
DOI: 10.1038/s43587-026-01123-0
PMCID: PMC13190297

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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