Article

<i>APOE4</i> drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes

2023-02-06

Abstract excerpt

<h4>Summary</h4> Apolipoprotein E4 (APOE4) is the strongest risk allele associated with the development of late onset Alzheimer’s disease (AD). Across the CNS, astrocytes are the predominant expressor of APOE while also being critical mediators of neuroinflammation and cerebral metabolism. APOE4 has been consistently linked with dysfunctional inflammation and metabolic processes, yet insights into the molecular...

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Literature Corpus work: fbd9c489-11f9-5847-9041-1023ca57f367
DOI: 10.1101/2023.02.06.527204

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