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Serum proteomics reveals early biomarkers of Alzheimer's disease: The dual role of APOE-ε4

22 Jan 2025

Abstract excerpt

Alzheimer's disease (AD), the leading cause of dementia, significantly impacts global public health, with cases expected to exceed 150 million by 2050. Late-onset Alzheimer's disease (LOAD), predominantly influenced by the APOE-ε4 allele, exhibits complex pathogenesis involving amyloid-β (Aβ) plaques, neurofibrillary tangles (NFTs), neuroinflammation, and blood-brain barrier (BBB) disruption. Proteomics has...

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PMID: 39842814
DOI: 10.5582/bst.2024.01365

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