Article
Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease.
Current opinion in neurobiology - 1 Dec 2011
Keene C Dirk, Cudaback Eiron, Li Xianwu, Montine Kathleen S, Montine Thomas J
Abstract excerpt
The largest genetic risk for late-onset Alzheimer's disease (AD) resides at the apolipoprotein E gene (APOE) locus, which has three common alleles (ɛ2, ɛ3, ɛ4) that encode three isoforms (apoE2, apoE3, apoE4). The very strong association of the APOE ɛ4 allele with AD risk and its role in the accumulation of amyloid β in brains of people and animal models solidify the biological relevance of apoE isoforms but do...
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