Article

Decoding the <i>MYC</i> locus reveals a druggable ultraconserved RNA element

2026-01-30

Abstract excerpt

<h4>ABSTRACT</h4> The human genome is dominated by noncoding sequences, most of which are poorly conserved across species. How genetic information is distributed between coding and noncoding regions remains a fundamental unresolved question. Using CRISPR saturation mutagenesis at base-pair resolution, we mapped the functional fitness landscape of the 10-kb human MYC locus with a near-PAMless, high-fidelity SpRY-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b1104e91-fac7-5f40-896e-ef4a582b60a6
DOI: 10.64898/2026.01.29.702547

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding the <i>MYC</i> locus reveals a druggable ultraconserved RNA elementDOI 10.64898/2026.01.29.702547Read

High-resolution interrogation of functional elements in the noncoding genomeSemantic proximity Read

High throughput PRIME editing screens identify functional DNA variants in the human genomeSemantic proximity Read

Scans of the <i>MYC</i> mRNA reveal multiple stable secondary structures—including a 3′ UTR motif, conserved across vertebrates, that can affect gene expressionSemantic proximity Read

Multi-locus CRISPRi targeting with a single truncated guide RNASemantic proximity Read

Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusionsSemantic proximity Read

Molecular principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precisionSemantic proximity Read

Sensitive, direct detection of non-coding off-target base editor unwinding and editing in primary cellsSemantic proximity Read

Cas9 targeted enrichment of mobile elements using nanopore sequencingSemantic proximity Read

Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusionsSemantic proximity Read

SynDesign: web-based prime editing guide RNA design and evaluation tool for saturation genome editing.Semantic proximity Read

Gigabase-scale deletion scanning of the human genomeSemantic proximity Read

MUTE-Seq: An Ultrasensitive Method for Detecting Low-Frequency Mutations in ctDNA with Engineered Advanced-Fidelity FnCas9Semantic proximity Read