Article

Scans of the MYC mRNA reveal multiple stable secondary structures—including a 3′ UTR motif, conserved across vertebrates, that can affect gene expression

2019-03-02

Abstract excerpt

The MYC gene encodes a human transcription factor and proto-oncogene that is dysregulated in over half of all known cancers. To better understand potential post-transcriptional regulatory features affecting MYC expression, we analyzed secondary structure in the MYC mRNA using a program that is optimized for finding small locally-folded motifs with a high propensity for function. This was accomplished by calcula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1db5d395-0d7b-5acf-bea1-38531cd4a02c
DOI: 10.1101/564864

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Scans of the MYC mRNA reveal multiple stable secondary structures—including a 3′ UTR motif, conserved across vertebrates, that can affect gene expressionDOI 10.1101/564864Read

Decoding the MYC locus reveals a druggable ultraconserved RNA elementSemantic proximity Read

Identification of MYC intron 2 regions that modulate expression.Semantic proximity Read

Genome-Wide Identification of Stable RNA Secondary Structures Across Multiple Organisms Using Chemical Probing Data: Insights into Short Structural Motifs and RNA-Targeting TherapeuticsSemantic proximity Read

Human Precursor microRNA Terminal Loop Regions Exhibit Distinct Sequence Characteristics and Motif EnrichmentSemantic proximity Read

Bioinformatics Analysis of Non-Coding UTR Variants in STAT1 Reveals Disruption of miRNA Binding, mRNA Stability, and Oncogenic PotentialSemantic proximity Read

Secondary Structural Model of Human MALAT1 Reveals Multiple Structure-Function Relationships.Semantic proximity Read

Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression.Semantic proximity Read

Searching for IRESSemantic proximity Read

Determinants of mRNA recognition and translation regulation by Lin28.Semantic proximity Read

The Presence of HIV-1 and HIV-2 Derived tRNA-like Motifs at Specific Intervals in Human Genes: Implications for the Regulation of Host SplicingSemantic proximity Read

Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activitySemantic proximity Read

RNA2DMut: a web tool for the design and analysis of RNA structure mutations.Semantic proximity Read

Scans of the <i>MYC</i> mRNA reveal multiple stable secondary structures—including a 3′ UTR motif, conserved across vertebrates, that can affect gene expression

Abstract excerpt

Topics

Identifiers and source

Related research