Article

Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusions

2022-06-28

Abstract excerpt

<title>Abstract</title> <p>Precision oncology programs can rapidly identify oncogenic gene fusions in individual patients<sup>1–3</sup>. However, despite their established oncogenic status, the vast majority of gene fusions remain ‘<italic>undruggable</italic>’ due to the lack of specific inhibitory molecules<sup>4,5</sup>. Here, we establish <italic>Psp</italic>Cas13b, a poorly characterized programmable RNA nuc...

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Literature Corpus work: 0f2de634-45e1-588d-8421-fcf21bfa4a4d
DOI: 10.21203/rs.3.rs-1714034/v1

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