Article

Gigabase-scale deletion scanning of the human genome

2026-06-02

Abstract excerpt

<h4>ABSTRACT</h4> What fraction of the human genome is essential for cellular viability? To date, essentiality in human cells has been mapped almost exclusively at the level of individual open reading frames (ORFs). Whether noncoding regions and broader architectural features of the genome are required for human cells to remain viable, and where the boundaries of any such regions lie, remains largely unexplored....

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Literature Corpus work: 3a5ef5da-cf01-58ca-9f42-a5bf73696f18
DOI: 10.64898/2026.05.29.728882

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