Article

Molecular principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision

2023-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Single nucleotide variants (SNVs) are extremely prevalent in human cancers. For instance, KRAS mutations occur in over 90% of pancreatic cancers and ∼40% of colorectal cancers. Virtually all KRAS mutations are SNVs, most of which remain clinically unactionable. The programmable RNA nuclease CRISPR-Cas13 has been deployed to specifically target RNAs such as overexpressed oncogenes and fusion tran...

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Literature Corpus work: ce649433-d83f-5c69-a48b-2aaa60460805
DOI: 10.1101/2023.09.26.557083

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