Article

Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusions

2022-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Precision oncology programs can rapidly identify oncogenic gene fusions in individual patients 1–3 . However, despite their established oncogenic status, the vast majority of gene fusions remain ‘ undruggable ’ due to the lack of specific inhibitory molecules 4, 5 . Here, we establish Psp Cas13b, a poorly characterized programmable RNA nuclease, as a versatile tool to silence various oncogen...

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Literature Corpus work: 332fbd9f-0dc9-5de2-9c29-7bf19c17a4cc
DOI: 10.1101/2022.06.22.497105

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