Article

Multi-locus CRISPRi targeting with a single truncated guide RNA

2023-10-21

Abstract excerpt

A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity of candidate elements. Here, we develop a CRISPRi- based approach for multi-locus screening of putative transcription factor binding sites with a single truncated guide. A truncated guide wit...

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Literature Corpus work: 2d530a1f-4abd-5c7f-812f-2e54de835e74
DOI: 10.1101/2023.10.20.563306

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