Article

High throughput PRIME editing screens identify functional DNA variants in the human genome

2023-07-12

Abstract excerpt

Despite tremendous progress in detecting DNA variants associated with human disease, interpreting their functional impact in a high-throughput and base-pair resolution manner remains challenging. Here, we develop a novel pooled prime editing screen method, PRIME, which can be applied to characterize thousands of coding and non-coding variants in a single experiment with high reproducibility. To showcase its applic...

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Literature Corpus work: 26319402-616a-5b72-b80a-b55162937862
DOI: 10.1101/2023.07.12.548736

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