Article

High-resolution interrogation of functional elements in the noncoding genome

2016-04-18

Abstract excerpt

The noncoding genome plays a major role in gene regulation and disease yet we lack tools for rapid identification and manipulation of noncoding elements. Here, we develop a large-scale CRISPR screen employing ~18,000 sgRNAs targeting >700 kb of noncoding sequence in an unbiased manner surrounding three genes ( NF1, NF2 , and CUL3 ) involved in resistance to the BRAF inhibitor vemurafenib in the BRAF -mutant mel...

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Identifiers and source

Literature Corpus work: 83583291-3711-5acd-bce7-7bf60f4610d0
DOI: 10.1101/049130

Open publication

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