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Global and local ancestry modulate<i>APOE</i>association with Alzheimer’s neuropathology and cognitive outcomes in an admixed sample

2022-02-04

Abstract excerpt

Dementia is more prevalent in Blacks than in Whites, likely due to a combination of environmental and biological factors. Paradoxically, clinical studies suggest an attenuation of APOE ε4 risk of dementia in African ancestry (AFR), but lack of neuropathological data preclude the interpretation of the biological factors underlying these findings, including the association between APOE ε4 risk and Alzheimer’s diseas...

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Literature Corpus work
b07ec9d1-bcc1-5fd4-ad8e-7cec26c8cb13
DOI
10.1101/2022.02.02.22270331
Open publication

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Global and local ancestry modulate<i>APOE</i>association with Alzheimer’s neuropathology and cognitive outcomes in an admixed sampleDOI 10.1101/2022.02.02.22270331
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