Dissecting the role of Amerindian genetic ancestry and the ApoE ε4 allele on Alzheimer disease in an admixed Peruvian population.

doi:10.1016/j.neurobiolaging.2020.10.003

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Dissecting the role of Amerindian genetic ancestry and the ApoE ε4 allele on Alzheimer disease in an admixed Peruvian population.

Neurobiology of aging - 1 May 2021

Marca-Ysabel Maria Victoria, Rajabli Farid, Cornejo-Olivas Mario, Whitehead Patrice G, Hofmann Natalia K, Illanes Manrique Maryenela Zaida, Veliz Otani Diego Martin, Milla Neyra Ana Karina, Castro Suarez Sheila, Meza Vega Maria, Adams Larry D, Mena Pedro R, Rosario Isasi, Cuccaro Michael L, Vance Jeffery M, Beecham Gary W, Custodio Nilton, Montesinos Rosa, Mazzetti Soler Pilar E, Pericak-Vance Margaret A

Abstract excerpt

Alzheimer disease (AD) is the leading cause of dementia in the elderly and occurs in all ethnic and racial groups. The apolipoprotein E (ApoE) ε4 is the most significant genetic risk factor for late-onset AD and shows the strongest effect among East Asian populations followed by non-Hispanic white populations and has a relatively lower effect in African descent populations. Admixture analysis in the African...

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PMID: 33541779
DOI: 10.1016/j.neurobiolaging.2020.10.003
PMCID: PMC8122013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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