Article
A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry.
PLoS genetics - 1 Jul 2022
Rajabli Farid, Beecham Gary W, Hendrie Hugh C, Baiyewu Olusegun, Ogunniyi Adesola, Gao Sujuan, Kushch Nicholas A, Lipkin-Vasquez Marina, Hamilton-Nelson Kara L, Young Juan I, Dykxhoorn Derek M, Nuytemans Karen, Kunkle Brian W, Wang Liyong, Jin Fulai, Liu Xiaoxiao, Feliciano-Astacio Briseida E, Schellenberg Gerard D, Dalgard Clifton L, Griswold Anthony J, Byrd Goldie S, Reitz Christiane, Cuccaro Michael L, Haines Jonathan L, Pericak-Vance Margaret A, Vance Jeffery M
Abstract excerpt
African descent populations have a lower Alzheimer disease risk from ApoE ε4 compared to other populations. Ancestry analysis showed that the difference in risk between African and European populations lies in the ancestral genomic background surrounding the ApoE locus (local ancestry). Identifying the mechanism(s) of this protection could lead to greater insight into the etiology of Alzheimer disease and more...
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