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Article

Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease.

JAMA - 21 Feb 2023

Le Guen Yann, Raulin Ana-Caroline, Logue Mark W, Sherva Richard, Belloy Michael E, Eger Sarah J, Chen Annabel, Kennedy Gabriel, Kuchenbecker Lindsey, O'Leary Justin P, Zhang Rui, Merritt Victoria C, Panizzon Matthew S, Hauger Richard L, Gaziano J Michael, Bu Guojun, Thornton Timothy A, Farrer Lindsay A, Napolioni Valerio, He Zihuai, Greicius Michael D

Abstract excerpt

Importance: Numerous studies have established the association of the common APOE ε2 and APOE ε4 alleles with Alzheimer disease (AD) risk across ancestries. Studies of the interaction of these alleles with other amino acid changes on APOE in non-European ancestries are lacking and may improve ancestry-specific risk prediction. Objective: To determine whether APOE amino acid changes specific to individuals of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36809323
DOI: 10.1001/jama.2023.0268
PMCID: PMC9945061

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