Article
Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample.
Molecular psychiatry - 1 Nov 2022
Naslavsky Michel Satya, Suemoto Claudia K, Brito Luciano Abreu, Scliar Marília Oliveira, Ferretti-Rebustini Renata Eloah, Rodriguez Roberta Diehl, Leite Renata E P, Araujo Nathalia Matta, Borda Victor, Tarazona-Santos Eduardo, Jacob-Filho Wilson, Pasqualucci Carlos, Nitrini Ricardo, Yaffe Kristine, Zatz Mayana, Grinberg Lea T
Abstract excerpt
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of environmental and biological factors. Paradoxically, clinical studies suggest an attenuation of APOE ε4 risk of dementia in African ancestry (AFR), but a dearth of neuropathological data preclude the interpretation of the biological factors underlying these findings, including the association between APOE ε4 risk and Alzheimer's...
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