Article

Ancestry-specific effects of <i>APOE</i> on Alzheimer Disease Endophenotypes

2026-03-25

Abstract excerpt

<h4>Importance</h4> APOE *ε4 is the strongest genetic risk factor for Alzheimer’s disease (AD), yet its effect varies across ancestral populations. As blood-based biomarkers increasingly inform AD diagnosis, failure to account for both APOE genotype and ancestry could lead to misinterpretation of biomarker profiles and inaccurate diagnostic classification. Understanding how ancestry modulates APOE effects is cr...

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Literature Corpus work: 2a1555ee-c3e3-54cf-8ff7-f13000d39fe7
DOI: 10.64898/2026.03.23.26349095

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