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Article

Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

5 Dec 2018

Abstract excerpt

The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by ε4, however, differs across populations, with populations of African ancestry showing lower ε4 risk compared to those of European or Asian ancestry. The cause of this heterogeneity in risk effect is currently unknown; it may be due to environmental or cultural factors correlated with ancestry, or...

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PMID: 30517106
DOI: 10.1371/journal.pgen.1007791

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