APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).

doi:10.1002/alz.12205

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Article

APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2021

Granot-Hershkovitz Einat, Tarraf Wassim, Kurniansyah Nuzulul, Daviglus Martha, Isasi Carmen R, Kaplan Robert, Lamar Melissa, Perreira Krista M, Wassertheil-Smoller Sylvia, Stickel Ariana, Thyagarajan Bharat, Zeng Donglin, Fornage Myriam, DeCarli Charles S, González Hector M, Sofer Tamar

Abstract excerpt

INTRODUCTION: Apolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry-specific genetic effects. METHODS: We investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183...

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PMID: 33155766
DOI: 10.1002/alz.12205
PMCID: PMC8016734

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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