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Is <i>APOE ε2</i> always a protective allele? Deviations in Hardy-Weinberg equilibrium in admixed Brazilian elderly individuals

2026-06-23

Abstract excerpt

<h4>ABSTRACT</h4> The APOE gene is a critical determinant of human healthspan and longevity, with the rare ε2 allele traditionally viewed as a universal protective factor against Alzheimer s disease (AD) and a driver of exceptional lifespan. However, this protective paradigm is predominantly derived from European-centric cohorts, leaving the evolutionary and clinical impacts of ε2 across diverse, highly admixed...

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Literature Corpus work
d1c0ee4f-f2f5-581f-aa00-9c413d349189
DOI
10.64898/2026.06.20.733520
Open publication

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Is <i>APOE ε2</i> always a protective allele? Deviations in Hardy-Weinberg equilibrium in admixed Brazilian elderly individualsDOI 10.64898/2026.06.20.733520
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