Article
Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2016
Hohman Timothy J, Cooke-Bailey Jessica N, Reitz Christiane, Jun Gyungah, Naj Adam, Beecham Gary W, Liu Zhi, Carney Regina M, Vance Jeffrey M, Cuccaro Michael L, Rajbhandary Ruchita, Vardarajan Badri Narayan, Wang Li-San, Valladares Otto, Lin Chiao-Feng, Larson Eric B, Graff-Radford Neill R, Evans Denis, De Jager Philip L, Crane Paul K, Buxbaum Joseph D, Murrell Jill R, Raj Towfique, Ertekin-Taner Nilufer, Logue Mark W, Baldwin Clinton T, Green Robert C, Barnes Lisa L, Cantwell Laura B, Fallin M Daniele, Go Rodney C P, Griffith Patrick, Obisesan Thomas O, Manly Jennifer J, Lunetta Kathryn L, Kamboh M Ilyas, Lopez Oscar L, Bennett David A, Hardy John, Hendrie Hugh C, Hall Kathleen S, Goate Alison M, Lang Rosalyn, Byrd Goldie S, Kukull Walter A, Foroud Tatiana M, Farrer Lindsay A, Martin Eden R, Pericak-Vance Margaret A, Schellenberg Gerard D, Mayeux Richard, Haines Jonathan L, Thornton-Wells Tricia A
Abstract excerpt
INTRODUCTION: African-American (AA) individuals have a higher risk for late-onset Alzheimer's disease (LOAD) than Americans of primarily European ancestry (EA). Recently, the largest genome-wide association study in AAs to date confirmed that six of the Alzheimer's disease (AD)-related genetic variants originally discovered in EA cohorts are also risk variants in AA; however, the risk attributable to many of the...
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