Back to search

Article

Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

2025-05-28

Abstract excerpt

<h4>Background</h4> Kidney transplantation is the preferred treatment strategy for end-stage kidney disease. Deceased donor kidneys usually undergo cold storage until kidney transplantation, leading to cold ischemia injury that may contribute to poor graft outcomes. However, the molecular characterization of potential mechanisms of cold ischemia injury remains incomplete. <h4>Results</h4> To bridge this knowledg...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
af66bfa9-ced8-58a4-a43d-bbc4b51a9f1f
DOI
10.1101/2025.05.25.654911
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changesDOI 10.1101/2025.05.25.654911
Hypoxic injury triggers maladaptive repair in human kidney organoidsSemantic proximity
Spatial metabolomics reveals persistent localized niche-specific metabolic failure in kidneys following ischemia-reperfusion injurySemantic proximity
Transcriptomic profiling during normothermic machine perfusion of human kidneys reveals a pro-inflammatory cellular landscape and gene expression signature associated with prolonged delayed graft function after transplantationSemantic proximity
Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.Semantic proximity
Thick ascending limb injury critically impacts kidney allograft survival after T-cell-mediated rejectionSemantic proximity
A comparative analysis of acellular versus red cell based subnormothermic machine perfusion in human kidney transplantationSemantic proximity
Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusionSemantic proximity
Spatial Transcriptomics Identify T Cell-Driven Mechanisms of Kidney Damage in Immune Checkpoint Inhibitor-Associated Acute Interstitial NephritisSemantic proximity
Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysisSemantic proximity
Spatially Resolved Transcriptomic Analysis of Acute Kidney Injury in a Female Murine ModelSemantic proximity
Spatial transcriptomics defines injury-specific microenvironments in the adult mouse kidney and novel cellular interactions in regeneration and diseaseSemantic proximity
Spatial transcriptomics defines injury specific microenvironments and cellular interactions in kidney regeneration and diseaseSemantic proximity
Select a neighboring publication to make it the new centre.