Thick ascending limb injury critically impacts kidney allograft survival after T-cell-mediated rejection

Abstract excerpt

<title>Abstract</title> <p>T-cell mediated rejection (TCMR) remains a significant challenge after kidney transplantation and is associated with reduced allograft outcome. Previous research highlighted the critical role of TCMR-induced renal epithelial injury. Yet, the detailed cellular origin of these injury responses and the associated clinical implications remain poorly understood. To induce acute TCMR, we used...

Topics

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• Acute Kidney Injury Research
• Chronic Kidney Disease and Diabetes
• Cytomegalovirus and herpesvirus research
• Dialysis and Renal Disease Management
• Organ Transplantation Techniques and Outcomes
• Renal and Vascular Pathologies
• Renal Transplantation Outcomes and Treatments
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

7b6efb24-9567-5423-9c2f-643dea94063e

DOI

10.21203/rs.3.rs-5683198/v1