Spatial Transcriptomics Identify T Cell-Driven Mechanisms of Kidney Damage in Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Immune checkpoint inhibitor-associated acute interstitial nephritis (ICI-AIN) is the most common finding on histopathology among patients with ICI-associated acute kidney injury (ICI-AKI). Patients with ICI-AIN often have T cell-dominant infiltration of the kidney and high tissue levels of CXCR3 ligands like CXCL9, 10, and 11; however, the mechanisms of inflammation in ICI...

Topics

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• Acute Kidney Injury Research
• Chronic Kidney Disease and Diabetes
• Dialysis and Renal Disease Management
• Renal and related cancers
• Renal and Vascular Pathologies
• Single-cell and spatial transcriptomics
• Tissue Engineering and Regenerative Medicine

Identifiers and source

Literature Corpus work

412fd20f-f3b2-522e-909a-9203bfa6f3bb

DOI

10.1101/2025.10.31.685702