Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.

doi:10.1681/ASN.2019080832

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Article

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.

Journal of the American Society of Nephrology : JASN - 1 Jan 2020

Dumas Sébastien J, Meta Elda, Borri Mila, Goveia Jermaine, Rohlenova Katerina, Conchinha Nadine V, Falkenberg Kim, Teuwen Laure-Anne, de Rooij Laura, Kalucka Joanna, Chen Rongyuan, Khan Shawez, Taverna Federico, Lu Weisi, Parys Magdalena, De Legher Carla, Vinckier Stefan, Karakach Tobias K, Schoonjans Luc, Lin Lin, Bolund Lars, Dewerchin Mieke, Eelen Guy, Rabelink Ton J, Li Xuri, Luo Yonglun, Carmeliet Peter

Abstract excerpt

BACKGROUND: Renal endothelial cells from glomerular, cortical, and medullary kidney compartments are exposed to different microenvironmental conditions and support specific kidney processes. However, the heterogeneous phenotypes of these cells remain incompletely inventoried. Osmotic homeostasis is vitally important for regulating cell volume and function, and in mammals, osmotic equilibrium is regulated through...

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PMID: 31818909
DOI: 10.1681/ASN.2019080832
PMCID: PMC6935008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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