Article

Hypoxic injury triggers maladaptive repair in human kidney organoids

2023-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Acute kidney injury (AKI) is a common clinical disorder linked to high rates of illness and death. Ischemia is a leading cause of AKI, which can result in chronic kidney disease (CKD) through maladaptive repair marked by impaired epithelial regeneration, inflammation, and metabolic dysregulation. There are no targeted therapies for AKI or to prevent progression to CKD and insight into human dise...

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Literature Corpus work: 5afb5560-7f16-51c7-a7da-ecfed367fe71
DOI: 10.1101/2023.10.04.558359

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